教育经历

2001–2007 内布拉斯加大学(University of Nebraska)，生物有机化学，博士 (David B Berkowitz 组)

1997-2001 中科院福建物质结构研究所，凝聚态物理， 硕士（陈创天院士组）

1993-1997 浙江师范大学，化学，本科

工作经历

2025-至今    昌平实验室 科学家，转化医学中心主任

2022-2025   深圳湾实验室 资深研究员，转化医学中心创始主任

2019-2022   深圳湾实验室化学生物学研究所 联合所长/召集人，转化医学中心主任（兼）

2018-2022   斯克里普斯研究所-Calibr（Calibr @ Scripps Research）代谢病总监

2012-2018   加州生物医药研究所（Calibr）创所首席研究员

2009-2012   诺华研究基金会基因组学研究所（GNF/Novartis）研究员II

2007-2009   斯克里普斯研究所（The Scripps Research Institute）化学生物学博士后 （Peter G Schultz组）

研究简介

致力于转化医学的研究，其研究领域包括：

1.  再生医学和衰老的化学生物学研究

2.  代谢类疾病和恶性肿瘤的药物研发

3.  小分子高通量筛选和多肽类药物的研发

主要荣誉

2023 入选国家重大工程人才计划

2023 鹏程优才（A）

2017 美中生物医药协会（SABPA）成就奖

2016 美中生物医药协会（SABPA）团队奖

2014 美中生物医药协会（SABPA）成就奖

2013 美中生物医药协会（SABPA）团队奖

2007 内布拉斯加大学诺曼・H・克伦威尔奖（Norman H Cromwell Award）

代表性成果

1. Nan Zheng*, Longfang Tu, Pu Xu, Rongfang Chen, Jiang Lu, Wan Dai, Yanxia Lin, Jianmei Ouyang, Jinying Qiu, You Wang, Leiming Wang, Weijun Shen*. Discovery and Preclinical Evaluation of TPM003:A Novel Glp-1/GIP/Glucagon Triple Hormone Receptor Agonist with Robust Efficacy in Obesity and NASH. J.Med.Chem. (2026)

2. Nan Zheng*, Rongfang Chen, Luying Yang, Pu Xu, Xueying Wang, Xin Sun, Yanxia Lin, Jinying Qiu, Xiao-xuan Su, You Wang, Leiming Wang, Weijun Shen*. Engineering of an Ultralong-Acting and Nonaggregating Dual Amylin and Calcitonin Receptor Agonist with Durable Efficacy in Obesity and Diabetes. J.Med.Chem. (2025)

3. Yanchao Pan*, Qing Xiang, Kai Deng, Muhammad I Anwar, Leiming Wang, Yuan Wang, Qiulian Liang, Lirou Shen, Jing Yang, Zhongyu Hou, Weijun Shen* Engineering IGF2 for Lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy Protein Sci.  (2025)

4. Ryan Watkins, Ana Gamo, Seung Hyuk Choi, Manoj Kumar, EeeLN Buckarma, Chantal McCabe, Jennifer Tomlinson, David Pereya, Blaz Lupse, Shirin Geravandi, Nathan W Werneburg, Chen Wang, Patrick Starlinger, Siying Zhu, Sijia Li, Shan Yu, Murali Surakattula, Tyler Baguley, Amin Ardestani, Kathrin Maedler, Jason Roland, Van Nguyen-Tran, Sean Joseph, Mike Petrassi, Nikki Rogers, Gregory Gores, Arnab Chatterjee*, Matthew Tremblay*, Weijun Shen* and Rory Smoot*. A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis. PNAS Nexus.  (2024)

5. Xinyu Li, Huimei Zeng, Pradeepraj Drairaj, Weihuan Wen, Tianpeng Li, Yanru Zhao, Yang Liu, Xue Liu, Lingpeng Zhan, Lang Rao, Wen Yuan, Tengfei Guo, Weijun Shen*, Hui Cai* and Zhicheng Chen*,  Fully synthetic phosphorylated Tau181, Tau217, and Tau231 calibrators for Alzheimer's disease diagnosis. Front Aging Neurosci. (2024)

6. Liu Y, Wang Z, Zhuang X, Zhang S, Chen Z, Zou Y, Sheng J, Li T, Tai W, Yu J, Wang Y, Zhang Z, Chen Y, Tong L, Yu X, Wu L, Chen D, Zhang R, Jin N, Shen Weijun*, Zhao J*, Tian M*, Wang X*, Cheng G*. Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants. Nature Commun. (2023)

7.  Yan Shi, Candy Lee , Peng Sang, Zaid Amso, David Huang, Weixia Zhong, Meng Gu, Lulu Wei, Vân T B Nguyen-Tran, Jingyao Zhang, Weijun Shen*, Jianfeng Cai*. α/Sulfono- γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo. Acta Pharm Sin B. (2023)

8. Yifang Yang, Candy Lee, Reddy Rajasekhar Reddy, David J Huang, Weixia Zhong, Vân T B Nguyen-Tran, Weijun Shen* and Qing Lin* Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists. ACS Chem Biol. (2022)

9. Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li,Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen- Tran, Sean   Joseph, Gokhan Hotamisligil, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay and Weijun Shen*. A Small Molecule UPR Modulator for Diabetes Identified by High Throughput Screening. Acta Pharm Sin B. (2021)

10. Sophia Shalhout, Peng-yu Yang, Edyta Grzelak, Kayla Nutsch, Sida Shao, Claudio Zambaldo, Jonathan Edyta, Lara Ibrahim, Caroline Stanton, Stormi Chadwick, Emily Chen, Michael DeRan, Sijia Li, Mitchell Hull, Xu Wu, Arnab Chatterjee, Weijun Shen*, Fernando Camargo*, Peter G. Schultz* and Michael J. Bollong*. Activation of YAP- dependent Proliferation by a Small Molecule Targeting Annexin A2. Nature Chem. Biology.( 2021)  

11. Sam Lear, Elsa Pflimlin, Zhihong Zhou, David Huang, Van T.B. Nguyen-Tran, Sean B.   Joseph, Shane Roller, Scott Peterson, Jing Li, Matthew Tremblay, Peter G. Schultz and Weijun Shen*. Engineering of a Potent, Long-Acting NPY2R  Agonist for Combination with a GLP- 1R Agonist to Mimic the Multi-Hormonal Effect of Bariatric Surgery. J. Med. Chem. (2020)

12. Sam Lear, Hyosuk Seo, Candy Lee, Lei Lei, Zaid Amso, David Huang, HuafeiZou, Zhihong Zhou, Vân T.B. Nguyen-Tran and Weijun Shen*. Recombinant Expression and Stapling of a Novel Long-Acting GLP- 1R Peptide Agonist. Molecules (2020) 

13. Peng Sang, Zhihong Zhou, Yan Shi, Candy Lee, Zaid Amso, David Huang, Timothy Odom, Vân T.B. Nguyen-Tran, Weijun Shen* and Jianfeng Cai*. The Activity of Sulfono-γ-AApeptide Helical Foldamers That Mimic GLP- 1 Science Advances (2020)

14. Amin Ardestani, Sijia Li, Karthika Annamalai, BlazLupse, Shirin Geravandi, Aleksandra Dobrowolski, Shan Yu, Siying Zhu, Tyler D. Baguley, Murali Surakattula, Janina Oetjen, Lena Hauberg-Lotte, Raquel Herranz, Sushil Awal, Delsi Altenhofen, Nguyen-Tran, Sean Joseph, Peter G Schultz, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay*, Weijun Shen* and Kathrin Maedler*.  “Neratinib Protects Pancreatic Beta Cells in Diabetes” Nature Comm. (2019)

15. Xuekai Zhang, Gang Lu, Meng Sun, Madhu Mahankali, Yanfei Ma, Mingming Zhang, Wangde Hua, Yuting Hu, Qingbing Wang, Jinghuo Chen, Gang He*, Xiangbing Qi*, Weijun  Shen*,  Peng  Liu*  and  Gong  Chen*.  “A  General  Strategy  for  Synthesis  of Cyclophane-Braced  Peptide  Macrocycles  via  Palladium-Catalyzed  Intramolecular  sp3 C−H Arylation” Nature Chemistry (2018)

16. Chris J. Novotny, Sirkku Pollari, Jin H. Park, Mark A. Lemmon, Weijun Shen* and Kevan M. Shokat*. Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding, Nature Chem Biol. (2016)

17. Peng-Yu Yang, Huafei Zou, Elizabeth Chao, Lance Sherwood, Vanessa Nunez, Michael Keeney, Esi Ghartey-Tagoe, ZhongliDing, Herlinda Quirino, Xiaozhou Luo, Gus Welzel, Guohua Chen, Parminder Singh, Ashley K. Woods*, Peter G. Schultz* and Weijun Shen*. Engineering a long-acting, potent GLP- 1 analog for microstructure- based transdermal delivery Proc Natl Acad Sci USA (2016)