Education

2001-2007,  University of Nebraska, Bioorganic Chemistry, Ph.D.

1997-2001,  Chinese Academy of Sciences, Condensed Matter Physics, M.S.

1993-1997,  Zhejiang Normal University, Chemistry, B.S.

Academic Experience

2025-present，Changping Laboratory, Beijing, Scientist and Founding Director of Center for Translational Research, CPL.

2022-2025, Shenzhen Bay Laboratory, Shenzhen, Senior PI and Director, Center for Translational Research, SZBL.

2019-2022, Shenzhen Bay Laboratory, Shenzhen, Institute of Chemical Biology, Co-Director and Founding Director of Center for Translational Research, SZBL.

Overview of Academic Research

Committed to translational medicine research, research areas include:

•   Chemical biology on regenerative medicine and aging.

•   Drug discovery for metabolic diseases and malignant tumors.

•   High-throughput screening of small molecules and development of peptide therapeutics.

Honors and Awards

2023, Selected for the Major National Talent Program

2023, Pengcheng Outstanding Talent Category A

2017, SABPA Achievement Award

2016, SABPA Team Award

2014, SABPA Achievement Award

2013, SABPA Team Award

2007, Norman H Cromwell Award, University of Nebraska

Representative Research Achievements 

1.  Nan Zheng*, Longfang Tu, Pu Xu, Rongfang Chen, Jiang Lu, Wan Dai, Yanxia Lin, Jianmei Ouyang, Jinying Qiu, You Wang, Leiming Wang, Weijun Shen*. Discovery and Preclinical Evaluation of TPM003:A Novel Glp-1/GIP/Glucagon Triple Hormone Receptor Agonist with Robust Efficacy in Obesity and NASH. J.Med.Chem. 2026 Feb 26;69(4):4984-5001. (2026)

2.  Nan Zheng*, Rongfang Chen, Luying Yang, Pu Xu, Xueying Wang, Xin Sun, Yanxia Lin, Jinying Qiu, Xiao-xuan Su, You Wang, Leiming Wang, Weijun Shen*. Engineering of an Ultralong-Acting and Nonaggregating Dual Amylin and Calcitonin Receptor Agonist with Durable Efficacy in Obesity and Diabetes. J.Med.Chem. 2025 Nov 27;68(22):24701-24717. (2025)

3.  Yanchao Pan*, Qing Xiang, Kai Deng, Muhammad I Anwar, Leiming Wang, Yuan Wang, Qiulian Liang, Lirou Shen, Jing Yang, Zhongyu Hou, Weijun Shen* Engineering IGF2 for Lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy, Protein Sci. 2025 Mar;34(3):e70051. (2025)

4.  Ryan Watkins, Ana Gamo, Seung Hyuk Choi, Manoj Kumar, EeeLN Buckarma, Chantal McCabe, Jennifer Tomlinson, David Pereya, Blaz Lupse, Shirin Geravandi, Nathan W Werneburg, Chen Wang, Patrick Starlinger, Siying Zhu, Sijia Li, Shan Yu, Murali Surakattula, Tyler Baguley, Amin Ardestani, Kathrin Maedler, Jason Roland, Van Nguyen-Tran, Sean Joseph, Mike Petrassi, Nikki Rogers, Gregory Gores, Arnab Chatterjee*, Matthew Tremblay*, Weijun Shen* and Rory Smoot*. A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis. PNAS Nexus. 2024 Mar 1;3(3):pgae096.  (2024)

5.  Xinyu Li, Huimei Zeng, Pradeepraj Drairaj, Weihuan Wen, Tianpeng Li, Yanru Zhao, Yang Liu, Xue Liu, Lingpeng Zhan, Lang Rao, Wen Yuan, Tengfei Guo, Weijun Shen*, Hui Cai* and Zhicheng Chen*,  Fully synthetic phosphorylated Tau181, Tau217, and Tau231 calibrators for Alzheimer's disease diagnosis. Front Aging Neuroscience (2023)15. (2024)

6.  Liu Y, Wang Z, Zhuang X, Zhang S, Chen Z, Zou Y, Sheng J, Li T, Tai W, Yu J, Wang Y, Zhang Z, Chen Y, Tong L, Yu X, Wu L, Chen D, Zhang R, Jin N, Shen Weijun*, Zhao J*, Tian M*, Wang X*, Cheng G*. Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants. Nature Commun. 2023 Apr 17;14:2179. (2023)

7.  Yan Shi, Candy Lee , Peng Sang, Zaid Amso, David Huang, Weixia Zhong, Meng Gu, Lulu Wei, Vân T B Nguyen-Tran, Jingyao Zhang, Weijun Shen*, Jianfeng Cai*. α/Sulfono- γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo. Acta Pharm Sin B. 2022 Oct 21;13(4):1648–1659.  (2023)

8.  Yifang Yang, Candy Lee, Reddy Rajasekhar Reddy, David J Huang, Weixia Zhong, Vân T B Nguyen-Tran, Weijun Shen* and Qing Lin* Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists. ACS Chem Biol. 2022, 17, 5, 1249–1258. (2022)

9. Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li,Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen- Tran, Sean   Joseph, Gokhan Hotamisligil, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay and Weijun Shen*. A Small Molecule UPR Modulator for Diabetes Identified by High Throughput Screening. Acta Pharm Sin B. 2021 Jun 16;11(12):3983–3993. (2021)

10. Sophia Shalhout, Peng-yu Yang, Edyta Grzelak, Kayla Nutsch, Sida Shao, Claudio Zambaldo, Jonathan Edyta, Lara Ibrahim, Caroline Stanton, Stormi Chadwick, Emily Chen, Michael DeRan, Sijia Li, Mitchell Hull, Xu Wu, Arnab Chatterjee, Weijun Shen*, Fernando Camargo*, Peter G. Schultz* and Michael J. Bollong*. YAP- dependent Proliferation by a Small Molecule Targeting Annexin A2. Nature Chemical Biology 2021, 17,767-775.( 2021)