教育经历

工作经历

2021-至今 昌平实验室，领衔科学家

2023-至今 北京大学生物医学前沿创新中心（BIOPIC），研究员、助理教授

2022-2023 北京大学生物医学前沿创新中心（BIOPIC），副研究员

2019-2022 北京大学生物医学前沿创新中心（BIOPIC），助理研究员

研究简介

曹云龙专注于免疫学研究，新冠疫情爆发后，带领科研团队围绕新冠病毒B细胞免疫应答、特异性抗体的结构与功能等开展了系统性研究，其中新冠中和抗体药物研制、新冠体液免疫应答特征和新冠突变免疫逃逸机制的创新性研究结果为抗击疫情做出了重要贡献。以第一作者、共同通讯作者在Nature、Cell、The Lancet Infectious Diseases、Cell Host & Microbe、Cell Research等期刊上发表多篇文章。主要成果如下：

1. 利用高通量单细胞VDJ测序快速从新冠康复者B细胞中筛选出大量新冠病毒高效中和抗体，并提出了一种中和抗体配对策略来应对新冠病毒突变。

2. 国际上最先揭示新冠奥密克戎株及其新亚型的免疫逃逸特征与分子机制。

3. 在全球最先系统性研究新冠病毒趋同进化现象，并率先构建新冠病毒RBD进化预测模型，为后续抗体药物和广谱疫苗的研制提供了科学理论与技术支撑。

主要荣誉

2022年度中国科学十大进展

2022年度中国生命科学十大进展

2022年度《自然》科学影响“十大人物”（Nature’s 10）

国家优秀青年科学基金获得者

2021年度《麻省理工科技评论》中国区“35岁以下科技创新35人”（TR35）

代表性成果

1.Yunlong Cao*, Fanchong Jian, Jing Wang, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Jing Wang, Ran An, Xiaosu Chen, Na Zhang, Yao Wang, Peng Wang, Lijuan Zhao, Haiyan Sun, Lingling Yu, Sijie Yang, Xiao Niu, Tianhe Xiao, Qingqing Gu, Fei Shao, Xiaohua Hao, Yanli Xu, Ronghua Jin, Zhongyang Shen, Youchun Wang*, Xiaoliang Sunney Xie*. Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. Nature (2022). https://doi.org/10.1038/s41586-022-05644-7

2.Yunlong Cao*, Ayijiang Yisimayi, Fanchong Jian, Weiliang Song, Tianhe Xiao, Lei Wang, Shuo Du, Jing Wang, Qianqian Li, Xiaosu Chen, Yuanling Yu, Peng Wang, Zhiying Zhang, Pulan Liu, Ran An, Xiaohua Hao, Yao Wang, Jing Wang, Rui Feng, Haiyan Sun, Lijuan Zhao, Wen Zhang, Dong Zhao, Jiang Zheng, Lingling Yu, Can Li, Na Zhang, Rui Wang, Xiao Niu, Sijie Yang, Xuetao Song, Yangyang Chai, Ye Hu, Yansong Shi, Linlin Zheng, Zhiqiang Li, Qingqing Gu, Fei Shao, Weijin Huang, Ronghua Jin, Zhongyang Shen*, Youchun Wang*, Xiangxi Wang*, Junyu Xiao*, Xiaoliang Sunney Xie*. BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature. 608: 593–602 (2022).

3.Yunlong Cao*, Jing Wang, Fanchong Jian, Tianhe Xiao, Weiliang Song, Ayijiang Yisimayi, Weijin Huang, Qianqian Li, Peng Wang, Ran An, Jing Wang, Yao Wang, Xiao Niu, Sijie Yang, Hui Liang, Haiyan Sun, Tao Li, Yuanling Yu, Qianqian Cui, Shuo Liu, Xiaodong Yang, Shuo Du, Zhiying Zhang, Xiaohua Hao, Fei Shao, Ronghua Jin, Xiangxi Wang*, Junyu Xiao*, Youchun Wang*, Xiaoliang Sunney Xie*. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature. 602: 657–663 (2022).

4.Zhen Cui, Pan Liu, Nan Wang, Lei Wang, Kaiyue Fan, Qianhui Zhu, Kang Wang, Ruihong Chen, Rui Feng, Zijing Jia, Minnan Yang, Ge Xu, Boling Zhu, Wangjun Fu, Tianming Chu, Leilei Feng, Yide Wang, Xinran Pei, Peng Yang, Xiaoliang Sunney Xie, Lei Cao*, Yunlong Cao*, Xiangxi Wang*. Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell. 185(5): 860-871. (2022)

5.Shuo Du, Yunlong Cao, Qinyu Zhu, Pin Yu, Feifei Qi, Guopeng Wang, Xiaoxia Du, Linlin Bao, Wei Deng, Hua Zhu, Jiangning Liu, Jianhui Nie, Yinghui Zheng, Haoyu Liang, Ruixue Liu, Shuran Gong, Hua Xu, Ayijiang Yisimayi, Qi Lv, Bo Wang, Runsheng He, Yunlin Han, Wenjie Zhao, Yali Bai, Yajin Qu, Xiang Gao, Chenggong Ji, Qisheng Wang, Ning Gao, Weijin Huang, Youchun Wang, Xiaoliang Sunney Xie*, Xiao-Dong Su*, Junyu Xiao*, Chuan Qin*. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell. 183: 1013-1023.e13 (2020).

6.Yunlong Cao, Bin Su, Xianghua Guo, Wenjie Sun, Yongqiang Deng, Linlin Bao, Qinyu Zhu, Xu Zhang, Yinghui Zheng, Chenyang Geng, Xiaoran Chai, Runsheng He, Xiaofeng Li, Qi Lv, Hua Zhu, Wei Deng, Yanfeng Xu, Yanjun Wang, Luxin Qiao, Yafang Tan, Liyang Song, Guopeng Wang, Xiaoxia Du, Ning Gao, Jiangning Liu, Junyu Xiao, Xiao-Dong Su, Zongmin Du, Yingmei Feng, Chuan Qin*, Chengfeng Qin*, Ronghua Jin*, Xiaoliang Sunney Xie*. Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells. Cell. 182: 73-84.e16 (2020).

7.Yunlong Cao*, Fanchong Jian, Zhiying Zhang, Ayijiang Yisimayi, Xiaohua Hao, Linlin Bao, Fei Yuan, Yuanling Yu, Shuo Du, Jing Wang, Tianhe Xiao, Weiliang Song, Ying Zhang, Pulan Liu, Ran An, Peng Wang, Yao Wang, Sijie Yang, Xiao Niu, Yuhang Zhang, Qingqing Gu, Fei Shao, Yaling Hu, Weidong Yin, Aihua Zheng, Youchun Wang, Chuan Qin*, Ronghua Jin*, Junyu Xiao*, Xiaoliang Sunney Xie*. Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Reports. 41(12): 111845 (2022).

8.Yunlong Cao*, Weiliang Song, Lei Wang, Pan Liu, Can Yue, Fanchong Jian, Yuanling Yu, Ayijiang Yisimayi, Peng Wang, Yao Wang, Qianhui Zhu, Jie Deng, Wangjun Fu, Lingling Yu, Na Zhang, Jing Wang, Tianhe Xiao, Ran An, Jing Wang, Lu Liu, Sijie Yang, Xiao Niu, Qingqing Gu, Fei Shao, Xiaohua Hao, Bo Meng, Ravindra Kumar Gupta, Ronghua Jin, Youchun Wang*, Xiaoliang Sunney Xie*. Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host & Microbe. 30(11): 1527-1539. (2022).

9.Fanchong Jian, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Lingling Yu, Yuxue Gao, Na Zhang, Yao Wang, Fei Shao, Xiaohua Hao, Yanli Xu, Ronghua Jin, Youchun Wang, Xiaoliang Sunney Xie*, Yunlong Cao*. Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants. The Lancet Infectious Diseases. 22(11): 1535-1537. (2022).

10.Yunlong Cao*, Xiaohua Hao, Xi Wang, Qianhui Wu, Rui Song, Dong Zhao, Weiliang Song, Yao Wang, Ayijiang Yisimayi, Wei Wang, Wen Zhang, Juan Du, Hongjie Yu*, Xiaoliang Sunney Xie*, Ronghua Jin*. Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine. Cell Research. 32: 107-109. (2022).