教育经历

 2002-2007，北京大学化学与分子工程学院，博士

 1998-2002，兰州大学化学化工学院，学士

工作经历

 2025.11-现在，   昌平实验室，领衔科学家

 2026.2-现在，     北京大学未来技术学院，教授

 2021.4-现在，     北京大学未来技术学院，长聘副教授

 2019.2-2021.4， 北京大学工学院，长聘副教授

 2013.2-2019.42，北京大学工学院，助理教授

 2007.7-2013.2，  哈佛大学化学与化学生物学系，博士后

研究简介

主要致力于新型植入式神经电极阵列的研制与脑机接口应用研究，在Nature Neuroscience、Nature Nanotechnology、Nature Communications等期刊发表文章20多篇，撰写专著1部，申请专利10余项。

研制出了1024通道/探针、长度1-9 厘米（覆盖从啮齿类到人脑的整脑深度）的“神经卷轴”探针，突破了其他电极记录通量与记录范围的物理极限，实现了猕猴大脑全深度、多脑区单神经元分辨率信号的同步、高通量记录，在大鼠上实现了长达105周（约为以往文献最长记录时间两倍）的神经元放电信号的连续稳定神经记录（Nature Neuroscience, 2024）；研制了形状自适应电极等多种大面积电极阵列，发展了大面积颅内皮层脑信号的微创采集技术，在啮齿类和犬类动物模型上揭示了癫痫态和麻醉觉醒过程中大范围皮层神经活动的时空动力学特性（Nature Communications 2024；ACS Nano 2019；Nature Communications 2018；Nano Letters 2018）；构建了磁共振成像兼容的深部脑刺激器件。在大鼠模型发现了刺激外侧缰核的高反应率、快速抗抑郁效果，在环路水平上解析了抗抑郁机理，揭示了抗抑郁效应与刺激位点的空间关联（eLife 2023；Nature Communications 2023，Nature Communications 2020）。

主要荣誉

  国家自然科学基金委青年科学基金项目A类获得者

  国家自然科学基金委优秀青年基金资助获得者

代表性成果

1.        Y. Liu, H. Jia, H. Sun, S. Jia, Z. Yang, A. Jiang, N. Yuji, C. Yang, S. Xue, X. Li, B. Chen, J. Zhu, X. Duan*, A high-density 1,024-channel probe for brain-wide recordings in non-human primates, Nature Neuroscience, 2024, 27(8): 1620-1631. 

2.        Wei S, Jiang A, Sun H, Zhu J, Jia S, Liu X, Xu Z, Zhang J, Shang Y, Fu X, Li G, Wang P, Xia Z, Jiang T, Cao A, Duan X*. Shape-changing electrode array for minimally invasive large-scale intracranial brain activity mapping. Nat Commun. 2024;15(1):715.  

3.        Li G, Bo B, Wang P, Qian P, Li M, Li Y, Tong C, Zhang K, Zhang B, Jiang T, Liang Z, Duan X*. Instantaneous antidepressant effect of lateral habenula deep brain stimulation in rats studied with functional MRI. eLife. 2023;12:e84693.  

4.        Yu Y, Qiu Y, Li G, Zhang K, Bo B, Pei M, Ye J, Thompson GJ, Cang J, Fang F, Feng Y, Duan X*, Tong C, Liang Z. Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice. Nat Commun. 2023;14(1):1651.  

5.        Liu X, Xu Z, Fu X, Liu Y, Jia H, Yang Z, Zhang J, Wei S, Duan X*. Stable, long-term single-neuronal recording from the rat spinal cord with flexible carbon nanotube fiber electrodes. J Neural Eng. 2022;19(5), 056024.

6.        Fu X, Li G, Niu Y, Xu J, Wang P, Zhou Z, Ye Z, Liu X, Xu Z, Yang Z, Zhang Y, Lei T, Zhang B, Li Q, Cao A, Jiang T, Duan X*. Carbon-Based Fiber Materials as Implantable Depth Neural Electrodes. Front Neurosci. 2021;15:771980.  

7.        Meng X, Cheng Y, Wang P, Chen K, Chen Z, Liu X, Fu X, Wang K, Liu K, Liu Z, Duan X*. Enhanced Hemocompatibility of a Direct Chemical Vapor Deposition-Derived Graphene Film. ACS Appl Mater Interfaces. 2021,13(4):4835-4843. 

8.        S. Zhao#, G. Li#, C. Tong, W. Chen, P. Wang, J. Dai, X. Fu, Z. Xu, X. Liu, L. Lu, Z. Liang*, X. Duan*, “Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes”, Nat. Commun., 11:1788 (2020).   

9.        S. Wei, R. Yin, T. Tang, Y. Wu, Y. Liu, P. Wang, K. Wang*, M. Mei, R. Zou, X. Duan*, “Gas-Permeable, Irritation-Free, Transparent Hydrogel Contact Lens Devices with Metal-Coated Nanofiber Mesh for Eye Interfacing”, ACS Nano, 2019, 13, 7, 7920-7929.  

10.      L. Lu, X. Fu, Y. Liew, Y. Zhang, S. Zhao, Z. Xu, J. Zhao, D. Li, Q. Li, G. B. Stanley, X. Duan*, “Soft and MRI Compatible Neural Electrodes from Carbon Nanotube Fibers”, Nano Lett., 19, 1577−1586 (2019).  

11.      R. Yin, Z. Xu, M. Mei, Z. Chen, K. Wang, Y. Liu, T. Tang, M. Priydarshi, X. Meng, S. Zhao, B. Deng, H. Peng, Z. Liu, X. Duan*, “Soft transparent graphene contact lens electrode for conformal, full-cornea recording of electroretinogram”, Nat. Commun., 9, 2334 (2018).  

12.      J. Zhang, X. Liu, W. Xu, W. Luo, M. Li, F. Chu, L. Xu, A. Cao, J. Guan, S. Tang, X. Duan*, “Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo”, Nano Lett. 18, 2903-2911 (2018).  

13.     S. Zhao, X. Liu, Z. Xu, H. Ren, B. Deng, M. Tang, L. Lu, X. Fu, H. Peng, Z. Liu, X. Duan*, “Graphene Encapsulated Copper Microwires as Highly MRI Compatible Neural Electrodes”, Nano Lett., 16, 7731-7738 (2016). 

14.     T.-M. Fu, X. Duan∗, Z. Jiang, X. Dai, P. Xie, Z. Cheng, C. M. Lieber∗ “Sub-10-nm intracellular bioelectronic probes from nanowire–nanotube heterostructures”, Proc. Natl. Acad. Sci. USA, 111, 1259-1264 (2014).

15.     X. Duan, R. Gao, P. Xie, T. Cohen-Karni, Q. Qing, H. Choe, B. Tian, X. Jiang, C. M. Lieber∗, “Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor”, Nature Nanotech., 7, 174-179 (2012).