教育经历

工作经历

研究简介

郭强课题组主要以电子光学为核心研究手段，在细胞内对亚细胞结构进行原位解析。在此基础上研究“细胞建筑学”：各个亚细胞结构是如何搭建成一个具有完整生物学功能的细胞；以及“生物大分子社会学”：细胞内的细胞器、生物大分子之间的相互关系。主要的研究方向包括：

1. 在纳米、亚纳米尺度对基础细胞生物学问题的研究

2. 对包括神经退行性疾病在内的老龄化疾病致病机制的研究

3. 病原微生物与宿主相互作用的亚细胞结构基础研究

4. 适用于组织样品的高分辨原位结构生物学方法开发与优化

主要荣誉

拜耳学者，2021

博雅青年学者，2021

億方学者，2020

Humboldt Fellowship， 2016

代表性成果

* co-first author, # corresponding author

1. Li, Z., Du, W., Yang, J., Lai, D.-H., Lun, Z.-R., Guo, Q.# (2023). Cryo-Electron Tomography of Toxoplasma gondii Indicates That the Conoid Fiber May Be Derived from Microtubules. Advanced Science n/a, 2206595.

2. Li, W.*, Lu, J.*, Xiao, K.*, Zhou, M.*, Li, Y., Zhang, X., Li, Z., Gu, L., Xu, X., Guo, Q.#, Xu, T.#, Ji, W.#, (2023). Integrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation. Nature Methods 20, 268-275.

3. Jiang, W., Wagner, J., Du, W., Plitzko, J., Baumeister, W., Beck, F.#, and Guo, Q.# (2022). A transformation clustering algorithm and its application in polyribosomes structural profiling. Nucleic Acids Research 50, 9001-9011.

4. Saha, I., Yuste-Checa, P., Da Silva Padilha, M., Guo, Q., Körner, R., Holthusen, H., Trinkaus, V.A., Dudanova, I., Fernández-Busnadiego, R., Baumeister, W., Sanders, D.W., Gautam, S., Diamond, M.I., Hartl, F.U.#, Hipp, M.S.#, (2023). The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nature Communications 14, 560.

5. Riemenschneider, H.*, Guo, Q.*, Bader, J., Frottin, F., Farny, D., Kleinberger, G., Haass, C., Mann, M., Hartl, F.U., Baumeister, W. et al. (2022) Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. EMBO Reports, 23, e53890

6. Trinkaus, V.A., Riera-Tur, I., Martínez-Sánchez, A., Bäuerlein, F.J.B., Guo, Q., Arzberger, T., Baumeister, W., Dudanova, I., Hipp, M.S., Hartl, F.U., et al. (2021). In situ architecture of neuronal α-Synuclein inclusions. Nature Communication. 12, 2110.

7. Yasuda, S., Tsuchiya, H., Kaiho, A., Guo, Q., Ikeuchi, K., Endo, A., Arai, N., Ohtake, F., Murata, S., Inada, T., et al. (2020). Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature 578, 296–300.

8. Guo, Q.*, Bin, H.*, Cheng, J., Seefelder, M., Engler, T., Pfeifer, G., Oeckl, P., Otto, M., Moser, F., Maurer, M., Pautsch, A., Baumeister, W.#, Fernandez-Busnadiego, R.#, Kochanek, S.# (2018). The cryo-electron microscopy structure of huntingtin. Nature 555, 117–120.

8. Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D.#, Baumeister, W.#, Fernandez-Busnadiego, R#. (2018) In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell 172, 696-705.e612.