教育经历

1999-2004 中科院上海有机化学研究所，有机化学博士

1995-1999 山东大学，化学学士

 

工作经历

2010-至今   教授，北京大学药学院

2007-2010  副教授，北京大学药学院

2004-2006  化学生物学博士后，洪堡奖学金，德国马普煤炭研究所

研究简介

长期致力于绿色合成化学、药物合成的绿色化、基于代谢类疾病的新药发现等研究，在 1）氧化反应；2）氮化反应；3）卤化反应等研究中取得了一系列创新性的成果，提出了简单碳氢化合物氮合反应的概念，利用氧气为氧化剂突破了氧合反应的瓶颈，解决了一些卤化试剂活化的关键问题。通过所发展的温和、绿色的氧化、氮化、卤化新反应完成药物活性中间体的高效合成及结构修饰改造，为布洛芬、酮洛芬、萘普生、扎托洛芬、雌酚、生育酚、花椒毒素，扁豆毒素，青藤碱等药物和天然产物的后期高效修饰提供了有效方法，所发现的关于用于光动力治疗、以及糖尿病性脂肪肝的 1 类候选药物临床前研究进展顺利。以通讯作者在Nature，Science，Nat. Chem.，Nat. Catal.等期刊发表论文 180 余篇，他引1.7 万余次。主编专著两部，授权专利 10 余项。

主要荣誉

2021 科学探索奖

2020 教育部自然科学一等奖（第一完成人）

2019 北京市自然科学一等奖（第一完成人）

2018 入选享受国务院特殊津贴专家

2017 国家有突出贡献中青年专家

2016 科技部中青年科技创新领军人才

2015 英国皇家化学会会士（FRSC）

 

代表性成果

1. Jia-Le Wang, Xiao-Dong Dou, Jie Cheng, Ming-Xin Gao, Guo-Feng Xu, Wei Ding, Jin-Hui Ding, Yu Li, Si-Han Wang, Zhao-Wei Ji, Xin-Yi Zhao, Tong-Yu Huo, Cai-Fang Zhang, Ya-Meng Liu, Xue-Ying Sha, Jia-Rui Gao, Wen-Hui Zhang, Cheng Zhang, Xiao Yu*, Ning Jiao*, Jin-Peng Sun*. From target identification to a therapeutic lead, functional screening- and rational design of compounds targeting GPR132 to treat diabetes. Nature Metabolism, in revision.
2. Xu Qiu, Yueqian Sang, Hao Wu, Xiao-Song Xue, Zixi Yan, Yachong Wang, Zengrui Cheng, Xiaoyang Wang, Hui Tan, Song Song, Guisheng Zhang, Xiaohui Zhang, K. N. Houk*, and Ning Jiao*. Cleaving arene rings for acyclic alkenylnitrile synthesis. Nature, 2021, 597: 64-69.
3. Yujie Liang, Shihui Shi, Rui Jin, Xu Qiu, Jialiang Wei, Hui Tan, Xue Jiang, Xiaomeng Shi, Song Song, and Ning Jiao*. Electrochemically induced nickel catalysis for oxygenation reactions with water. Nat. Catal., 2021, 4: 116-123.
4. Jianzhong Liu, Cheng Zhang, Ziyao Zhang, Xiaojin Wen, Xiaodong Dou, Jialiang Wei, Xu Qiu, Song Song, and Ning Jiao*. Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles. Science, 2020, 367: 281-285.

5. Song Song, Xinyao Li, Jialiang Wei, Weijin Wang, Yiqun Zhang, Lingsheng Ai, Yuchao Zhu, Xiaomeng Shi, Xiaohui Zhang and Ning Jiao*. DMSO-Catalyzed Late-Stage Chlorination of (Hetero)Arenes. Nat. Catal. , 2020, 3: 107-115.

6. Jianzhong Liu, Xu Qiu, Xiaoqiang Huang, Xiao Luo, Jialiang Wei, Jun Pan, Yujie Liang, Yuchao Zhu, Qixue Qin, Song Song, and Ning Jiao*. From Alkylarenes to Anilines via Site-Directed Carbon-Carbon Amination. Nat. Chem., 2019, 11: 71-77.

7. Jun Pan, Xinyao Li, Fengguirong Lin, Jianzhong Liu, Ning Jiao*. Chemoselective Nitrosylation of Anilines and Alkynes via Fragmentary or Complete ‘NO’ Incorporation. Chem., 2018, 4: 1427-1442.

8. Yuchao Zhu, Kaimeng Hunag, Jun Pan, Xu Qiu, Xiao Luo, Qixue Qin, Jialiang Wei, Xiaojin Wen, Lizhi Zhang, and Ning Jiao*. Silver-Catalyzed Remote Csp3-H Functionalization of Aliphatic Alcohols. Nature Commun., 2018, 9: 2625.
9. Yu-Feng Liang, and Ning Jiao*. Oxygenation via C‒H/C‒C Bond Activation with Molecular Oxygen. Acc. Chem. Res., 2017, 50: 1640-1653 (Invited).
10. Teng Wang, and Ning Jiao*. Direct Approaches to Nitriles via Highly Efficient Nitrogenation Strategy through C–H or C–C Bond Cleavage. Acc. Chem. Res., 2014, 47: 1137-1145 (Invited Contribution).